Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.84 |
| ▸ | DRD2 | P14416 | 1/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.67 |
| ▸ | HTR2B | P41595 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11280882 | 1.00 | POLB (0.84) | POLBDRD2HTR2AHTR2BPKM | |
| Hydrochloric Acid SCHEMBL11562609 | 0.98 | POLB (0.82) | POLBDRD2HTR2AHTR2BPKM | |
| SCHEMBL11558226 | 0.90 | POLB (0.68) | POLBDRD2HTR2AHTR2BPKM | |
| SCHEMBL11560061 | 0.90 | POLB (0.68) | POLBDRD2HTR2AHTR2BPKM | |
| SCHEMBL11562714 | 0.89 | POLB (0.67) | POLBDRD2HTR2AHTR2BPKM | |
| Hydrochloric Acid SCHEMBL11560896 | 0.82 | POLB (0.75) | POLBDRD2HTR2AHTR2BPKM | |
| SCHEMBL11560231 | 0.81 | CACNA1C (0.62) | POLBDRD2HTR2AHTR2BPKM | |
| SCHEMBL10937736 | 0.81 | POLB (0.60) | POLBDRD2HTR2AHTR2BPKM | |
| SCHEMBL10937733 | 0.81 | POLB (0.60) | POLBDRD2HTR2AHTR2BPKM | |
| SCHEMBL11272212 | 0.81 | POLB (0.55) | POLBDRD2HTR2AHTR2BPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4147804-A | ANTIARRHYTHMIA AGENTS | WILLIAM H. RORER, INC. (US) | 1979-04-03 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |