Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 7/20 | 0.41 |
| ▸ | REN | P00797 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PEPD | P12955 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11276976 | 0.89 | KMT2A (0.48) | KMT2AACERENKDM4EF2 | |
| SCHEMBL11326757 | 0.89 | KMT2A (0.48) | KMT2AACERENKDM4EF2 | |
| SCHEMBL683520 | 0.85 | CMA1 (0.55) | ACEACE2CMA1 | |
| SCHEMBL11271096 | 0.85 | CMA1 (0.55) | ACEACE2CMA1 | |
| SCHEMBL683120 | 0.83 | SLC6A2 (0.52) | ACECMA1 | |
| SCHEMBL683525 | 0.81 | CMA1 (0.48) | ACEACE2CMA1 | |
| SCHEMBL11278644 | 0.79 | KMT2A (0.48) | KMT2AACEMAPTCAPN1CTSB | |
| SCHEMBL11090289 | 0.79 | KMT2A (0.53) | KMT2ACAPN1CTSB | |
| SCHEMBL11280725 | 0.79 | ITGB1 (0.43) | ACERENKDM4EF2LMNA | |
| SCHEMBL3189279 | 0.79 | KMT2A (0.56) | KMT2AF2LMNAMAPTCAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007477-B1 | 1-(3-MERCAPTO-2-METHYLPROPANOYL)PROLYL AMINO ACID DERIVATIVES AND SALTS THEREOF, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 1982-04-28 | — | — | EP | disclosed |
| US-4248883-A | ANTIHYPERTENSION AGENTS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1981-02-03 | — | — | US | disclosed |
| EP-0007477-A1 | 1-(3-Mercapto-2-methylpropanoyl)prolyl amino acid derivatives and salts thereof, processes for their preparation, and pharmaceutical compositions containing such compounds | Dainippon Pharmaceutical Co., Ltd. (JP) | 1980-02-06 | — | — | EP | disclosed |