Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3867305 | 0.84 | HPGD (0.60) | MEN1HPGDKMT2AHSD17B10TDP1 | |
| SCHEMBL7618324 | 0.83 | MEN1 (0.58) | MEN1HPGDKMT2AHSD17B10TDP1 | |
| SCHEMBL6179506 | 0.83 | MEN1 (0.58) | MEN1HPGDKMT2AHSD17B10TDP1 | |
| SCHEMBL24421919 | 0.81 | MEN1 (0.57) | MEN1HPGDKMT2AHSD17B10TDP1 | |
| SCHEMBL21917711 | 0.81 | MEN1 (0.57) | MEN1HPGDKMT2AHSD17B10TDP1 | |
| SCHEMBL32660137 | 0.81 | MEN1 (0.57) | MEN1HPGDKMT2AHSD17B10TDP1 | |
| SCHEMBL22320027 | 0.80 | MEN1 (0.55) | MEN1HPGDKMT2AHSD17B10TDP1 | |
| Hydrochloric Acid SCHEMBL7246926 | 0.80 | MEN1 (0.55) | MEN1HPGDKMT2AHSD17B10TDP1 | |
| SCHEMBL1027011 | 0.80 | HPGD (0.68) | MEN1HPGDKMT2AHSD17B10TDP1 | |
| SCHEMBL2146965 | 0.80 | MEN1 (0.68) | MEN1HPGDKMT2AHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282762-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | Intermune, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |