Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14736624 | 0.80 | NOTUM (0.63) | NOTUMNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL3614850 | 0.78 | NOTUM (0.56) | NOTUMNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10103644 | 0.76 | NOTUM (0.62) | NOTUMNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL27628551 | 0.75 | NOTUM (0.60) | NOTUMNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL91656 | 0.74 | SMN1; SMN2 (0.70) | NOTUMNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4865554 | 0.74 | NOTUM (0.68) | NOTUMNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4865565 | 0.74 | NOTUM (1.00) | NOTUMNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL15058774 | 0.74 | FFAR1 (0.66) | NOTUMNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL14122701 | 0.74 | NOTUM (0.63) | NOTUMNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL16284866 | 0.74 | NPC1 (0.65) | NOTUMNPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0061882-A1 | Process for preparing isoxazol-3-ylcarboxamides | ELI LILLY AND COMPANY (US) | 1982-10-06 | — | — | EP | disclosed |