Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 19/20 | 0.52 |
| ▸ | HCAR3 | P49019 | 14/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3101166 | 0.86 | HCAR2 (0.54) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL11293467 | 0.85 | HCAR2 (0.72) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3105849 | 0.80 | HCAR2 (0.74) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3098814 | 0.78 | HCAR2 (0.73) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3099785 | 0.77 | HCAR2 (0.74) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3097421 | 0.77 | HCAR2 (0.74) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3103599 | 0.76 | HCAR2 (0.74) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL11301212 | 0.75 | HCAR2 (0.52) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3094326 | 0.75 | HCAR2 (0.59) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3093524 | 0.75 | HCAR2 (0.77) | HCAR2HCAR3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0006305-B1 | DERIVATIVES OF 4,5-DIHYDRO-4-OXOFURAN-2-CARBOXYLIC ACID, ESPECIALLY FOR USE AS HYPOLIPIDEMIC AGENTS, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, TETRAHYDROPYRAN-2,3,5-TRIONES USEFUL IN THE PREPARATION OF THE SAID DERIVATIVES AND A PROCESS FOR PREPARING THESE TETRAHYDROPYRAN-2,3,5-TRIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-08-11 | — | — | EP | disclosed |
| US-4244958-A | Hypolipidemic derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-01-13 | — | — | US | disclosed |
| WO-1980000025-A1 | DERIVATIVES OF 4,5-DIHYDRO-4-OXOFURAN-2-CARBOXYLIC ACID,PREPARATIONS AND USE THEREOF AND TETRAHYDROPYRAN-2,3,5-TRIONE INTERMEDIATES | AMERICAN HOME PROD (US) | 1980-01-10 | — | — | WO | disclosed |
| EP-0006305-A1 | Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid, especially for use as hypolipidemic agents, processes for their preparation, pharmaceutical compositions comprising them, tetrahydropyran-2,3,5-triones useful in the preparation of the said derivatives and a process for preparing these tetrahydropyran-2,3,5-triones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-01-09 | — | — | EP | disclosed |
| US-4169202-A | Process for preparing 4,5-dihydro-4-oxofuran-2-carboxylic acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1979-09-25 | — | — | US | disclosed |