Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 11/20 | 0.86 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.86 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.75 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.75 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.75 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.75 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.75 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11301979 | 1.00 | GPBAR1 (0.86) | GPBAR1NR1H4NR3C1MEN1KMT2A | |
| SCHEMBL11294557 | 1.00 | GPBAR1 (0.86) | GPBAR1NR1H4NR3C1MEN1KMT2A | |
| SCHEMBL24712916 | 0.92 | GPBAR1 (1.00) | GPBAR1NR1H4NR3C1MEN1KMT2A | |
| SCHEMBL10109673 | 0.92 | GPBAR1 (1.00) | GPBAR1NR1H4NR3C1MEN1KMT2A | |
| SCHEMBL19116123 | 0.92 | GPBAR1 (1.00) | GPBAR1NR1H4NR3C1MEN1KMT2A | |
| SCHEMBL9760600 | 0.92 | GPBAR1 (1.00) | GPBAR1NR1H4NR3C1MEN1KMT2A | |
| SCHEMBL10123477 | 0.92 | GPBAR1 (1.00) | GPBAR1NR1H4NR3C1MEN1KMT2A | |
| SCHEMBL593794 | 0.92 | GPBAR1 (1.00) | GPBAR1NR1H4NR3C1MEN1KMT2A | |
| SCHEMBL9760793 | 0.92 | GPBAR1 (1.00) | GPBAR1NR1H4NR3C1MEN1KMT2A | |
| SCHEMBL5525191 | 0.92 | GPBAR1 (1.00) | GPBAR1NR1H4NR3C1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0018515-B1 | PROCESS FOR THE PREPARATION OF CHENODEOXYCHOLIC ACID AND INTERMEDIATE PRODUCTS | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-10-27 | — | — | EP | disclosed |
| US-4301246-A | HYDROXYLATION OF 3-KETO-BISNORCHOLENOL TO 7-HYDROXY-3-KETO-BISNORCHOLENOL | HOFFMANN-LA ROCHE INC. (US) | 1981-11-17 | — | — | US | disclosed |
| EP-0018515-A2 | Process for the preparation of chenodeoxycholic acid and intermediate products | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-11-12 | — | — | EP | disclosed |
| US-4230625-A | DISSOLVING GALLSTONES | HOFFMANN-LA ROCHE INC. (US) | 1980-10-28 | — | — | US | disclosed |