Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2436117 | 1.00 | PREP (0.32) | PREPKDM4EMEN1KMT2A | |
| SCHEMBL2436120 | 1.00 | PREP (0.32) | PREPKDM4EMEN1KMT2A | |
| SCHEMBL5684885 | 0.74 | PREP (0.36) | PREP | |
| SCHEMBL427185 | 0.74 | KMT2A (0.33) | KDM4EMEN1KMT2A | |
| SCHEMBL882859 | 0.74 | KMT2A (0.33) | KDM4EMEN1KMT2A | |
| SCHEMBL426527 | 0.74 | KMT2A (0.33) | KDM4EMEN1KMT2A | |
| SCHEMBL12300710 | 0.69 | MEN1 (0.39) | KDM4EMEN1KMT2A | |
| SCHEMBL754295 | 0.68 | PREP (0.34) | PREP | |
| SCHEMBL11307712 | 0.67 | MEN1 (0.38) | KDM4EMEN1KMT2A | |
| SCHEMBL29860057 | 0.64 | PREP (0.33) | PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288400-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-16 | — | — | US | disclosed |
| US-20120183577-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120183577-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP3K1, MAP3K6 | PREP 3022/4885KDM4E 2132/4885MEN1 1496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.