Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 12/20 | 0.48 |
| ▸ | PIM1 | P11309 | 9/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 7/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14554060 | 0.85 | PIM2 (0.34) | PIM2PIM1PIM3 | |
| SCHEMBL2177985 | 0.83 | PIM2 (0.66) | PIM2PIM1PIM3 | |
| SCHEMBL25229968 | 0.83 | PIM2 (0.48) | PIM2PIM1PIM3 | |
| SCHEMBL27081307 | 0.79 | PDE4B (0.34) | PIM2PIM1PIM3 | |
| SCHEMBL2177884 | 0.79 | PIM2 (0.71) | PIM2PIM1PIM3 | |
| SCHEMBL30422172 | 0.79 | PIM2 (0.71) | PIM2PIM1PIM3 | |
| SCHEMBL11305149 | 0.78 | PIM2 (0.53) | PIM2PIM1PIM3 | |
| SCHEMBL14762261 | 0.77 | PIM1 (0.62) | PIM2PIM1PIM3 | |
| SCHEMBL12494693 | 0.77 | PIM3 (0.66) | PIM2PIM1PIM3 | |
| SCHEMBL2178502 | 0.76 | PIM3 (0.66) | PIM2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098387-A1 | 6, 7-RING-FUSED TRIAZOLO [4, 3 - B] PYRIDAZINE DERIVATIVES AS PIM INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-07-26 | — | — | WO | disclosed |