Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 1/20 | 0.55 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | CDK4 | P11802 | 2/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CCND3 | P30281 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11025081 | 0.92 | STAT6 (0.55) | STAT6SLC2A1PTK2NPC1RAB9A | |
| SCHEMBL11031861 | 0.85 | SLC2A1 (0.55) | STAT6SLC2A1NPC1RAB9AAURKA | |
| SCHEMBL11029285 | 0.85 | SLC2A1 (0.49) | STAT6SLC2A1PTK2AURKACDK2 | |
| SCHEMBL11030519 | 0.85 | MAPKAPK2 (0.49) | STAT6SLC2A1PTK2AURKACDK2 | |
| SCHEMBL11029599 | 0.85 | MAPKAPK2 (0.58) | STAT6SLC2A1AURKACDK2CDK4 | |
| SCHEMBL11030017 | 0.84 | STAT6 (0.48) | STAT6SLC2A1PTK2NPC1RAB9A | |
| SCHEMBL11030049 | 0.84 | SLC2A1 (0.51) | STAT6SLC2A1NPC1RAB9AAURKA | |
| SCHEMBL11030040 | 0.84 | SLC2A1 (0.51) | STAT6SLC2A1NPC1RAB9AAURKA | |
| SCHEMBL11033167 | 0.84 | BTK (0.48) | STAT6SLC2A1PTK2AURKACDK2 | |
| SCHEMBL11028029 | 0.84 | CDK4 (0.53) | STAT6SLC2A1PTK2AURKACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665711-A1 | PICOLINAMIDE INHIBITORS OF KINASES | Abbvie Inc. (US) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012100135-A1 | PICOLINAMIDE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2012-07-26 | — | — | WO | disclosed |