Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.72 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.60 |
| ▸ | KDM4A | O75164 | 1/20 | 0.59 |
| ▸ | KDM5A | P29375 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7239123 | 0.92 | HDAC1 (0.70) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL9404065 | 0.92 | MAPT (0.71) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL11588924 | 0.90 | MAPT (0.68) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL28609434 | 0.88 | MAPT (0.77) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL11137519 | 0.88 | MAPT (0.77) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL1508071 | 0.88 | MAPT (0.77) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL4886613 | 0.86 | MAPT (0.73) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL9404058 | 0.86 | MAPT (0.62) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL9403984 | 0.86 | MAPT (0.62) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL9404056 | 0.86 | MAPT (0.62) | MAPTRXFP1HDAC1HDAC2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632452-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | ProMetic BioSciences Inc. (CA) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012097428-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR USES IN DIABETES | PROMETIC BIOSCIENCES INC. (CA) | 2012-07-26 | — | — | WO | disclosed |
| WO-2012097427-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | PROMETIC BIOSCIENCES INC. (CA) | 2012-07-26 | — | — | WO | disclosed |