Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 19/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | LATS1 | O95835 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | INSRR | P14616 | 1/20 | 0.37 |
| ▸ | FECH | P22830 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | MARK3 | P27448 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4359809 | 0.91 | TNK2 (0.47) | TNK2RIPK2ROCK2LATS1INSR | |
| SCHEMBL593984 | 0.91 | TNK2 (0.47) | TNK2RIPK2ROCK2LATS1INSR | |
| SCHEMBL4370132 | 0.88 | TNK2 (0.40) | TNK2RIPK2ROCK2LATS1INSR | |
| SCHEMBL593295 | 0.88 | TNK2 (0.40) | TNK2RIPK2ROCK2LATS1INSR | |
| SCHEMBL1566724 | 0.80 | TNK2 (0.41) | TNK2IGF1R | |
| SCHEMBL14948254 | 0.78 | TNK2 (0.48) | TNK2RIPK2ROCK2LATS1INSR | |
| SCHEMBL399554 | 0.78 | TNK2 (0.37) | TNK2RIPK2ROCK2LATS1INSR | |
| SCHEMBL1129097 | 0.77 | TNK2 (0.47) | TNK2RIPK2ROCK2LATS1INSR | |
| SCHEMBL594577 | 0.77 | TNK2 (0.47) | TNK2RIPK2ROCK2LATS1INSR | |
| SCHEMBL593721 | 0.77 | TNK2 (0.61) | TNK2RIPK2ROCK2LATS1INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283020-A1 | SUBSTITUTED IMIDAZOPYR-AND IMIDAZOTRI-AZINES | OSI Pharmaceuticals, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009143051-A1 | SUBSTITUTED IMIDAZOPYR-AND IMIDAZOTRI-AZINES | OSI PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | WO | disclosed |