Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | GPR183 | P32249 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2873071 | 0.90 | MAPK1 (0.65) | MAPK1KMT2AHSD17B10KDM4ENPC1 | |
| SCHEMBL17197259 | 0.89 | MAPK1 (0.54) | MAPK1KMT2AHSD17B10KDM4ENPC1 | |
| SCHEMBL31316090 | 0.89 | MAPK1 (0.54) | MAPK1KMT2AHSD17B10KDM4ENPC1 | |
| SCHEMBL17197305 | 0.89 | MAPK1 (0.54) | MAPK1KMT2AHSD17B10KDM4ENPC1 | |
| SCHEMBL8793697 | 0.84 | MAPK1 (0.56) | MAPK1KMT2AHSD17B10KDM4ENPC1 | |
| SCHEMBL18759935 | 0.84 | ESR1 (0.62) | MAPK1KMT2AHSD17B10KDM4ENPC1 | |
| SCHEMBL22864557 | 0.84 | ESR1 (0.62) | MAPK1KMT2AHSD17B10KDM4ENPC1 | |
| SCHEMBL26133774 | 0.83 | KDM4E (0.55) | MAPK1KMT2AHSD17B10KDM4ENPC1 | |
| SCHEMBL31412994 | 0.83 | MAPK1 (0.54) | MAPK1KMT2AHSD17B10KDM4ENPC1 | |
| SCHEMBL15754254 | 0.83 | NR1H2 (0.64) | MAPK1KMT2AHSD17B10KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117730083-A | Pyrimidine compounds as MAP4K1 inhibitors | 格兰马克专业公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-114555585-A | HPK1 inhibitors and uses thereof | 上海齐鲁锐格医药研发有限公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-113227049-A | Indolinone compounds as MAP4K1 inhibitors | 艾科诺斯科技股份有限公司 | 2021-08-06 | — | — | CN | disclosed |
| EP-2665727-A1 | BICYCLIC CARBOXAMIDE INHIBITORS OF KINASES | Abbvie Inc. (US) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012097684-A1 | BICYCLIC CARBOXAMIDE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2012-07-26 | — | — | WO | disclosed |