Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31504568 | 0.81 | NPC1 (0.41) | NPC1MAPK1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL14380921 | 0.77 | MKNK1 (0.55) | MKNK1MKNK2TSHRMAPK1HPGD | |
| SCHEMBL14894230 | 0.73 | HPGD (0.42) | MKNK1MKNK2TSHRMAPK1HPGD | |
| SCHEMBL4622801 | 0.73 | TNKS (0.55) | TSHRMAPK1HPGDUSP2NPSR1 | |
| SCHEMBL28379997 | 0.72 | SMN1; SMN2 (0.55) | MAPK1ALDH1A1SMN1; SMN2POLBEP300 | |
| SCHEMBL1269528 | 0.71 | MKNK1 (0.41) | MKNK1MKNK2TSHRMAPK1HPGD | |
| SCHEMBL12124539 | 0.70 | NPC1 (0.69) | NPC1 | |
| SCHEMBL11343195 | 0.70 | MIF (0.60) | TSHRMAPK1HPGDUSP2NPSR1 | |
| SCHEMBL5124111 | 0.69 | SMN1; SMN2 (0.39) | HPGDALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL23874925 | 0.69 | MAPT (0.36) | NPC1TSHRMAPK1NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4366319-A | Process for preparing 5-(pyridinyl)benzoxazol-2(3H)-ones | STERLING DRUG INC. (US) | 1982-12-28 | — | — | US | disclosed |
| US-4310531-A | 5-(Pyridinyl)-benzoxazol-2(3H)-ones and their use as cardiotonics | STERLING DRUG INC. (US) | 1982-01-12 | — | — | US | disclosed |