Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11301824 | 0.84 | KDM4E (0.39) | ALOX15PCSK9KDM4ESLC6A2SLC6A4 | |
| SCHEMBL28363673 | 0.80 | NOTUM (0.43) | KDM4ESLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL11299962 | 0.75 | SLC6A4 (0.39) | KDM4EMAPTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11296509 | 0.75 | KDR (0.43) | KDM4EMAPTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11301394 | 0.74 | SLC6A2 (0.40) | KDM4EMAPTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18361035 | 0.74 | NOTUM (0.46) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL18361366 | 0.71 | MEN1 (0.44) | KDM4EMAPTSLC6A4ALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL21043567 | 0.70 | MEN1 (0.44) | KDM4EMAPTSLC6A4CYP2D6ALDH1A1 | |
| SCHEMBL11306334 | 0.70 | HDAC1 (0.45) | ALOX15KDM4ESLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18361056 | 0.69 | MEN1 (0.41) | KDM4EMAPTSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |