Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 16/20 | 0.66 |
| ▸ | DYRK1B | Q9Y463 | 14/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11296064 | 0.99 | DYRK1A (0.66) | DYRK1ADYRK1BLCKFGFR1EGFR | |
| Hydrochloric Acid SCHEMBL11301200 | 0.96 | DYRK1A (0.64) | DYRK1ADYRK1B | |
| SCHEMBL11296038 | 0.87 | DYRK1A (0.70) | DYRK1ADYRK1B | |
| SCHEMBL10446582 | 0.87 | DYRK1A (0.67) | DYRK1ADYRK1BLCKFGFR1EGFR | |
| Hydrochloric Acid SCHEMBL11303167 | 0.87 | DYRK1A (0.69) | DYRK1ADYRK1B | |
| Hydrochloric Acid SCHEMBL11297738 | 0.84 | DYRK1A (0.63) | DYRK1ADYRK1B | |
| SCHEMBL10446561 | 0.83 | DYRK1A (0.68) | DYRK1ADYRK1B | |
| SCHEMBL10324490 | 0.83 | DYRK1A (0.69) | DYRK1ADYRK1BLCKFGFR1EGFR | |
| SCHEMBL11298554 | 0.83 | DYRK1A (0.79) | DYRK1ADYRK1B | |
| Hydrochloric Acid SCHEMBL11297652 | 0.83 | DYRK1A (0.68) | DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098065-A1 | PYRIDO PYRIMIDINES FOR USE AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | claimed |
| WO-2012098065-A1 | PYRIDO PYRIMIDINES FOR USE AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |