Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11296174 | 0.85 | HDAC8 (0.44) | HDAC6HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL11297519 | 0.84 | HDAC6 (0.43) | HDAC6HDAC1HDAC8MMP13 | |
| SCHEMBL11301404 | 0.84 | HDAC8 (0.47) | HDAC6HDAC1HDAC8MMP13 | |
| SCHEMBL11302647 | 0.83 | HDAC6 (0.43) | HDAC6HDAC1HDAC8HDAC11GPR6 | |
| SCHEMBL11298752 | 0.83 | HDAC8 (0.42) | HDAC6HDAC1HDAC8 | |
| SCHEMBL11296595 | 0.83 | HDAC6 (0.42) | HDAC6HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL11297424 | 0.83 | HDAC1 (0.43) | HDAC6HDAC1HDAC8 | |
| SCHEMBL11301397 | 0.83 | HDAC1 (0.39) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL11296122 | 0.83 | HDAC6 (0.43) | HDAC6HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL11301754 | 0.82 | PSEN1 (0.42) | HDAC6HDAC1HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | claimed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | claimed |