Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 17/20 | 0.53 |
| ▸ | INSR | P06213 | 2/20 | 0.47 |
| ▸ | IGF1R | P08069 | 2/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | FECH | P22830 | 1/20 | 0.37 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.37 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.37 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.37 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.37 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129116 | 0.93 | TNK2 (0.46) | TNK2INSRIGF1RCYP2C19 | |
| SCHEMBL1129114 | 0.93 | TNK2 (0.46) | TNK2INSRIGF1RCYP2C19 | |
| SCHEMBL1128888 | 0.91 | TNK2 (0.58) | TNK2INSRIGF1R | |
| SCHEMBL1128889 | 0.91 | TNK2 (0.58) | TNK2INSRIGF1R | |
| SCHEMBL12017838 | 0.86 | TNK2 (0.42) | TNK2INSRIGF1RCYP2C19 | |
| SCHEMBL1758849 | 0.86 | TNK2 (0.42) | TNK2INSRIGF1RCYP2C19 | |
| SCHEMBL12017839 | 0.83 | TNK2 (0.53) | TNK2INSRIGF1R | |
| SCHEMBL1759191 | 0.83 | TNK2 (0.53) | TNK2INSRIGF1R | |
| SCHEMBL12005338 | 0.82 | TNK2 (0.46) | TNK2INSRIGF1R | |
| SCHEMBL13618207 | 0.78 | TNK2 (0.59) | TNK2INSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283020-A1 | SUBSTITUTED IMIDAZOPYR-AND IMIDAZOTRI-AZINES | OSI Pharmaceuticals, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009143051-A1 | SUBSTITUTED IMIDAZOPYR-AND IMIDAZOTRI-AZINES | OSI PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | WO | disclosed |