Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.46 |
| ▸ | PPARG | P37231 | 7/20 | 0.46 |
| ▸ | PPARD | Q03181 | 7/20 | 0.46 |
| ▸ | PPARA | Q07869 | 7/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TLR2 | O60603 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | FABP4 | P15090 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11211450 | 1.00 | KMT2A (0.52) | KMT2AMAPTTSHRLMNANFKB1 | |
| SCHEMBL11291283 | 0.86 | KMT2A (0.55) | KMT2AMAPTTSHRGPR84PPARG | |
| SCHEMBL11519181 | 0.83 | KMT2A (0.56) | KMT2AMAPTTSHRLMNANFKB1 | |
| SCHEMBL5744776 | 0.83 | KMT2A (0.56) | KMT2AMAPTTSHRLMNANFKB1 | |
| SCHEMBL12970907 | 0.83 | KMT2A (0.56) | KMT2AMAPTTSHRLMNANFKB1 | |
| SCHEMBL22612520 | 0.81 | TSHR (0.52) | KMT2ATSHRLMNANFKB1PMP22 | |
| SCHEMBL2928747 | 0.81 | TSHR (0.52) | KMT2ATSHRLMNANFKB1PMP22 | |
| SCHEMBL22612532 | 0.81 | TSHR (0.52) | KMT2ATSHRLMNANFKB1PMP22 | |
| SCHEMBL22612512 | 0.81 | TSHR (0.52) | KMT2ATSHRLMNANFKB1PMP22 | |
| SCHEMBL494627 | 0.81 | TSHR (0.52) | KMT2ATSHRLMNANFKB1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0022157-B1 | 3-METHYL-5-KETO-ALPHA,OMEGA-ALKENDIOIC ACIDS AND THEIR ESTERS, PROCESS FOR THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF MACROCYCLIC BETA-METHYL KETONES | HAARMANN & REIMER GMBH (DE) | 1981-12-23 | — | — | EP | disclosed |
| US-4259518-A | 3-Methyl-5-keto-α,ω-alkenedioic acids and esters | BAYER AKTIENGESELLSCHAFT (DE) | 1981-03-31 | — | — | US | disclosed |