Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133647 | 1.00 | MAPT (0.50) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL14670125 | 0.88 | POLB (0.41) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL15755541 | 0.88 | POLB (0.41) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL12669736 | 0.82 | MAPT (0.52) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL1133709 | 0.81 | KDM4E (0.44) | MAPTKMT2AMEN1HPGDGAA | |
| SCHEMBL15756052 | 0.80 | GAA (0.45) | MAPTALDH1A1HPGDGAAKDM4E | |
| SCHEMBL15756054 | 0.80 | GAA (0.45) | MAPTALDH1A1HPGDGAAKDM4E | |
| SCHEMBL12880093 | 0.78 | RECQL (0.46) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL1865392 | 0.77 | MAPT (0.47) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL1865394 | 0.77 | MAPT (0.47) | MAPTALDH1A1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285801-B1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | disclosed |
| EP-2285801-B1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | disclosed |
| US-8399668-B2 | Process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxamides | NERVIANO MEDICAL SCIENCES S. R. L. (IT) | 2013-03-19 | — | — | US | disclosed |
| US-8399668-B2 | Process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxamides | NERVIANO MEDICAL SCIENCES S. R. L. (IT) | 2013-03-19 | — | — | US | disclosed |
| US-8399668-B2 | Process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxamides | NERVIANO MEDICAL SCIENCES S. R. L. (IT) | 2013-03-19 | — | — | US | disclosed |
| EP-2285801-A1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | Nerviano Medical Sciences S.r.l. (IT) | 2011-02-23 | — | — | EP | disclosed |
| US-20110040090-A1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-02-17 | — | — | US | disclosed |
| US-20110040090-A1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-02-17 | — | — | US | disclosed |
| US-20110040090-A1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-02-17 | — | — | US | disclosed |
| WO-2009133170-A1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-11-05 | — | — | WO | disclosed |
| WO-2009133170-A1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110040090-A1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | CDC7, CDK7, CDK17 | MAPT 3460/4885ALDH1A1 3974/4885KMT2A 1243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.