Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 6/20 | 0.34 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.34 |
| ▸ | TRPV2 | Q9Y5S1 | 2/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 3/20 | 0.32 |
| ▸ | CDK8 | P49336 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11321221 | 0.92 | CNR2 (0.35) | CNR2CNR1TRPA1TRPV1TRPV3 | |
| Hydrochloric Acid SCHEMBL11323597 | 0.92 | CNR2 (0.34) | CNR2CNR1TRPA1TRPV1TRPV3 | |
| Hydrochloric Acid SCHEMBL11332101 | 0.91 | CCNC (0.34) | CNR2CNR1TRPA1TRPV1TRPV3 | |
| Hydrochloric Acid SCHEMBL11340178 | 0.90 | CNR2 (0.34) | CNR2CNR1TRPA1TRPV1TRPV3 | |
| Hydrochloric Acid SCHEMBL11321215 | 0.88 | CNR2 (0.35) | CNR2CNR1TRPA1TRPV1TRPV3 | |
| Bromide SCHEMBL11336914 | 0.87 | CNR2 (0.32) | CNR2ALOX15CCNCCDK8HASPIN | |
| Hydrochloric Acid SCHEMBL11334442 | 0.84 | CNR2 (0.41) | CNR2CNR1TRPA1TRPV1TRPV3 | |
| Hydrochloric Acid SCHEMBL11336862 | 0.84 | CNR2 (0.35) | CNR2CNR1TRPA1TRPV1TRPV3 | |
| Hydrochloric Acid SCHEMBL11328831 | 0.84 | CNR2 (0.40) | CNR2CNR1TRPA1TRPV1TRPV3 | |
| Hydrochloric Acid SCHEMBL11337772 | 0.84 | CNR2 (0.40) | CNR2CNR1TRPA1TRPV1TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4254116-A | ANALGESICS, ANTIDEPRESSANTS, NEUTRALIZING AGENTS | ABBOTT LABORATORIES (US) | 1981-03-03 | — | — | US | disclosed |