Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CD40 | P25942 | 1/20 | 0.41 |
| ▸ | CD40LG | P29965 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10995545 | 0.94 | CD40 (0.41) | KMT2APOLBCD40CD40LGTTR | |
| SCHEMBL11346155 | 0.88 | KMT2A (0.40) | KMT2APOLBIDH1KDRLCK | |
| SCHEMBL11346735 | 0.87 | CD40 (0.45) | KMT2APOLBCD40CD40LGIDH1 | |
| SCHEMBL11340787 | 0.85 | PRMT1 (0.41) | KMT2APOLBIDH1KDRLCK | |
| SCHEMBL10823411 | 0.85 | IDH1 (0.55) | IDH1IDH2 | |
| SCHEMBL11348122 | 0.84 | KMT2A (0.51) | KMT2APOLBCD40CD40LGKDR | |
| SCHEMBL11341346 | 0.83 | CD40 (0.52) | KMT2ACD40CD40LGCA1CA2 | |
| SCHEMBL11341037 | 0.83 | KMT2A (0.52) | KMT2APOLBCD40CD40LGIDH1 | |
| SCHEMBL11344331 | 0.83 | HPSE (0.47) | KMT2APOLBCD40CD40LGIDH1 | |
| SCHEMBL10907561 | 0.82 | MAOB (0.40) | KMT2APOLBCD40CD40LGBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297372-A | ANTIARTHRITIC AGENTS; COLLAGENASE AND PROTEOLYTIC ENZYME INHIBITORS; BONE, SKIN, AND ORAL DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0013784-A1 | C-Substituted naphthalenemonosulfonic ureides, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4216164-A | Ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |