Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 2/20 | 0.74 |
| ▸ | CASP6 | P55212 | 3/20 | 0.60 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.60 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.57 |
| ▸ | NT5E | P21589 | 1/20 | 0.50 |
| ▸ | NSD2 | O96028 | 2/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | TIMP3 | P35625 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11342568 | 0.95 | PRMT1 (0.67) | PRMT1CASP6CTDSP1SIRT1NT5E | |
| SCHEMBL10907815 | 0.93 | PRMT1 (0.63) | PRMT1CASP6CTDSP1SIRT1NT5E | |
| SCHEMBL11345132 | 0.92 | PRMT1 (0.62) | PRMT1CASP6CTDSP1SIRT1NT5E | |
| SCHEMBL10908508 | 0.89 | PRMT1 (0.57) | PRMT1CASP6CTDSP1SIRT1NT5E | |
| SCHEMBL11339129 | 0.88 | PRMT1 (0.56) | PRMT1CASP6CTDSP1SIRT1NT5E | |
| SCHEMBL6079067 | 0.86 | PRMT1 (1.00) | PRMT1CASP6CTDSP1SIRT1NT5E | |
| SCHEMBL2679101 | 0.86 | PRMT1 (1.00) | PRMT1CASP6CTDSP1SIRT1NT5E | |
| SCHEMBL29349608 | 0.86 | PRMT1 (1.00) | PRMT1CASP6CTDSP1SIRT1NT5E | |
| SCHEMBL10909518 | 0.85 | NT5E (0.61) | PRMT1CASP6CTDSP1SIRT1NT5E | |
| SCHEMBL11346336 | 0.84 | PRMT1 (0.55) | PRMT1CASP6CTDSP1SIRT1NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297372-A | ANTIARTHRITIC AGENTS; COLLAGENASE AND PROTEOLYTIC ENZYME INHIBITORS; BONE, SKIN, AND ORAL DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0013784-A1 | C-Substituted naphthalenemonosulfonic ureides, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4216164-A | Ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |