Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1134567 | 0.94 | SCNN1A (0.61) | SCNN1A | |
| Trifluoroacetic Acid SCHEMBL1429046 | 0.82 | SCNN1A (0.56) | SCNN1AKCNH2 | |
| Trifluoroacetic Acid SCHEMBL1134656 | 0.82 | SCNN1A (0.50) | SCNN1A | |
| SCHEMBL2074093 | 0.79 | SCNN1A (0.56) | SCNN1AKCNH2 | |
| Trifluoroacetic Acid SCHEMBL1428034 | 0.78 | SCNN1A (0.49) | SCNN1AKCNH2 | |
| Hydrochloric Acid SCHEMBL1134670 | 0.78 | SCNN1A (0.55) | SCNN1AKCNH2 | |
| Hydrochloric Acid SCHEMBL1134530 | 0.78 | SCNN1A (0.55) | SCNN1AKCNH2 | |
| Trifluoroacetic Acid SCHEMBL1134632 | 0.77 | KCNH2 (0.67) | SCNN1AKCNH2 | |
| SCHEMBL4313502 | 0.77 | POLB (0.44) | — | |
| SCHEMBL12379799 | 0.77 | SCNN1A (0.54) | SCNN1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110059989-A1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF AIRWAY DISEASES | NOVARTIS AG (CH) | 2011-03-10 | — | — | US | disclosed |
| EP-2285785-A1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES | Novartis AG (CH) | 2011-02-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059989-A1 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF AIRWAY DISEASES | CFTR, SCN5A, SCNN1B | SCNN1A 7/4885KCNH2 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.