Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | TYMP | P19971 | 3/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | TACR2 | P21452 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SHBG | P04278 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28621111 | 0.83 | SKP2 (0.46) | SKP2SRCHTR2AALDH1A1TYR | |
| SCHEMBL28459291 | 0.82 | SKP2 (0.48) | SKP2SRCHTR2AALDH1A1TYR | |
| SCHEMBL28248002 | 0.82 | SKP2 (0.48) | SKP2SRCHTR2AALDH1A1TYR | |
| SCHEMBL5567215 | 0.82 | SKP2 (0.48) | SKP2SRCHTR2AALDH1A1TYR | |
| SCHEMBL9516123 | 0.82 | SKP2 (0.48) | SKP2SRCHTR2AALDH1A1TYR | |
| SCHEMBL294503 | 0.82 | SKP2 (0.48) | SKP2SRCHTR2AALDH1A1TYR | |
| SCHEMBL31521779 | 0.82 | SKP2 (0.48) | SKP2SRCHTR2AALDH1A1TYR | |
| SCHEMBL1498860 | 0.82 | SKP2 (0.48) | SKP2SRCHTR2AALDH1A1TYR | |
| SCHEMBL11345756 | 0.81 | SKP2 (0.46) | SKP2SRCHTR2AALDH1A1TYR | |
| SCHEMBL5329916 | 0.81 | SKP2 (0.46) | SKP2SRCHTR2AALDH1A1TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216999-B2 | Substituted pyrrolo[2,3-h][1,6]naphthyridines and compositions thereof as JAK inhibitors | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2015-12-22 | — | — | US | disclosed |
| US-4261926-A | REACTION WITH KETONE IN PRESENCE OF PLATINUM HYDROGENATION CATALYST AND A PROMOTER ACID | AMERICAN CYANAMID COMPANY (US) | 1981-04-14 | — | — | US | disclosed |