SCHEMBL11348169

SCHEMBL11348169

CC(C)(C)NCC(O)Cn1ccnc1[N+](=O)[O-]

nearest known ligand 0.62

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.62
LMNA P02545 1/20 0.44
THRB P10828 1/20 0.44
CYP2C19 P33261 1/20 0.44
CA12 O43570 4/20 0.42
CA1 P00915 4/20 0.42
CA2 P00918 4/20 0.42
CA9 Q16790 4/20 0.42
ADRB2 P07550 6/20 0.42
ADRB1 P08588 6/20 0.42
ADRB3 P13945 6/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
OPRK1 P41145 1/20 0.41
TYMP P19971 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11455609 0.99 KMT2A (0.60) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL8855479 0.89 KMT2A (0.58) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL9085256 0.89 KMT2A (0.58) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL8855640 0.88 KMT2A (0.57) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL8855648 0.88 KMT2A (0.57) KMT2ALMNATHRBCYP2C19CA12
Bromide SCHEMBL8855683 0.88 KMT2A (0.57) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL8855592 0.88 KMT2A (0.57) KMT2ALMNATHRBCYP2C19CA12
Bromide SCHEMBL8855602 0.87 KMT2A (0.56) KMT2ALMNATHRBCYP2C19CA12
Hydrochloric Acid SCHEMBL8855620 0.87 KMT2A (0.56) KMT2ALMNATHRBCYP2C19CA12
Hydrochloric Acid SCHEMBL8855469 0.87 KMT2A (0.56) KMT2ALMNATHRBCYP2C19CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0000928-B1 NITROIMIDAZOLES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS WELL AS THEIR PREPARATION F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1981-03-18 EP claimed
US-4241060-A FOR SENSITIZING HYPOXIC CELLS TO RADIATION; ANTIPROTOZAL AGENTS HOFFMANN-LA ROCHE INC. (US) 1980-12-23 US claimed
EP-0000928-B1 NITROIMIDAZOLES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS WELL AS THEIR PREPARATION F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1981-03-18 EP disclosed
US-4241060-A FOR SENSITIZING HYPOXIC CELLS TO RADIATION; ANTIPROTOZAL AGENTS HOFFMANN-LA ROCHE INC. (US) 1980-12-23 US disclosed