Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.67 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10601227 | 0.91 | TSHR (0.65) | AKR1B1AKR1B10MAPTAKR1A1TSHR | |
| SCHEMBL11341929 | 0.82 | AKR1B1 (0.67) | AKR1B1TSHRTDP1 | |
| SCHEMBL448629 | 0.82 | AKR1B1 (0.67) | AKR1B1AKR1A1TSHRTDP1 | |
| SCHEMBL7867873 | 0.81 | TSHR (0.63) | AKR1B1AKR1B10MAPTAKR1A1TSHR | |
| SCHEMBL1395366 | 0.80 | AKR1B1 (1.00) | AKR1B1TSHRTDP1 | |
| SCHEMBL11338031 | 0.79 | AKR1B1 (0.62) | AKR1B1TSHRTDP1 | |
| SCHEMBL10604042 | 0.78 | AKR1B1 (0.59) | AKR1B1AKR1B10MAPTAKR1A1TSHR | |
| SCHEMBL11152497 | 0.78 | KDM1A (0.44) | AKR1B1AKR1B10MAPTAKR1A1 | |
| SCHEMBL11334633 | 0.78 | AKR1B1 (0.60) | AKR1B1TSHRTDP1 | |
| SCHEMBL10608762 | 0.77 | AKR1B1 (0.53) | AKR1B1AKR1B10MAPTAKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4282229-A | FOR DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |
| US-4258054-A | ANTIDIABETIC | PFIZER INC. (US) | 1981-03-24 | — | — | US | disclosed |
| US-4210756-A | Tetrahydroquinoline hydantoins for chronic diabetic complications | PFIZER INC. (US) | 1980-07-01 | — | — | US | disclosed |
| US-4209630-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1980-06-24 | — | — | US | disclosed |
| US-4147795-A | ENZYME INHIBITORS | PFIZER INC. (US) | 1979-04-03 | — | — | US | disclosed |
| US-4117230-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1978-09-26 | — | — | US | disclosed |