Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.33 |
| ▸ | QPCT | Q16769 | 3/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11357490 | 0.92 | HRH4 (0.38) | HRH4QPCTHRH2NAMPTCYP3A4 | |
| SCHEMBL11353418 | 0.88 | HRH4 (0.36) | HRH4P2RX7QPCTHRH2NAMPT | |
| SCHEMBL11366603 | 0.87 | HRH4 (0.34) | HRH4QPCTHRH2CYP3A4CYP2D6 | |
| SCHEMBL11367692 | 0.87 | HRH4 (0.45) | HRH4P2RX7HRH2CYP3A4CYP2D6 | |
| SCHEMBL11357224 | 0.86 | HRH4 (0.39) | HRH4P2RX7HRH2CYP3A4CYP2D6 | |
| SCHEMBL11367836 | 0.85 | CYP3A4 (0.31) | HRH4QPCTNAMPTCYP3A4CYP2D6 | |
| SCHEMBL11371217 | 0.83 | BCHE (0.39) | HRH4P2RX7HRH2CYP2C19 | |
| SCHEMBL11353639 | 0.81 | HRH4 (0.33) | HRH4HRH2NAMPTCYP3A4CYP2D6 | |
| SCHEMBL11369819 | 0.81 | HRH4 (0.37) | HRH4QPCTHRH2NAMPTCYP3A4 | |
| SCHEMBL11369824 | 0.81 | HRH4 (0.37) | HRH4QPCTHRH2NAMPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4293699-A | CONTAINING A BENZIMIDAZOLE OR 3-/5,6,7,8-TETRAHYDROIMIDAZO(1,5A)PYRIDINE, ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-10-06 | — | — | US | disclosed |
| US-4287198-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-09-01 | — | — | US | disclosed |
| US-4228291-A | INHIBITORS OF HISTAMINE ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-10-14 | — | — | US | disclosed |
| US-4221802-A | Pharmacologically active guanidine compounds for inhibiting H-2 histamine receptors | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-09-09 | — | — | US | disclosed |
| US-4154844-A | ANTIHISTAMINE, GASTRIC JUICE ANTISECRETORY AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-15 | — | — | US | disclosed |
| US-4137237-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-01-30 | — | — | US | disclosed |
| US-4070475-A | THIOALKYL-, AMINOALKYL-, AND OXYALKYL- SUBSTITUTED GUANIDINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1978-01-24 | — | — | US | disclosed |
| US-4024271-A | INHIBITORS OF HISTAMINE ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-17 | — | — | US | disclosed |
| US-4022797-A | PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-10 | — | — | US | disclosed |
| US-3950333-A | HISTAMINE INHIBITORS, OXYALKYL, THIOALKYL, AMINOALKYL DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-04-13 | — | — | US | disclosed |