Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 6/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.44 |
| ▸ | PTGIR | P43119 | 2/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.44 |
| ▸ | PTGFR | P43088 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SLCO2A1 | Q92959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11369425 | 0.91 | HTT (0.48) | HTTPTGER2PTGER4PTGER3PTGIR | |
| SCHEMBL13236667 | 0.84 | HTT (0.62) | HTTPTGER2PTGER4PTGER3PTGIR | |
| SCHEMBL8822913 | 0.83 | HTT (0.48) | HTTPTGER2PTGER4PTGER3PTGIR | |
| SCHEMBL8822910 | 0.83 | HTT (0.48) | HTTPTGER2PTGER4PTGER3PTGIR | |
| SCHEMBL8822916 | 0.83 | HTT (0.48) | HTTPTGER2PTGER4PTGER3PTGIR | |
| SCHEMBL11366948 | 0.83 | PTGER4 (0.48) | HTTPTGER2PTGER4PTGER3PTGIR | |
| SCHEMBL11367155 | 0.83 | PTGER2 (0.47) | HTTPTGER2PTGER4PTGER3PTGIR | |
| SCHEMBL9127017 | 0.82 | PTGDR2 (0.52) | HTTPTGER2PTGER4PTGER3PTGIR | |
| SCHEMBL9127033 | 0.82 | PTGDR2 (0.52) | HTTPTGER2PTGER4PTGER3PTGIR | |
| SCHEMBL16504094 | 0.82 | PTGDR2 (0.52) | HTTPTGER2PTGER4PTGER3PTGIR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4212993-A | 11-ALKYL-13-SATURATED-15-KETO-16-FLUORO, -ALKYL OR -TRIFLUOROMETHYL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 1980-07-15 | — | — | US | claimed |
| EP-0000207-A1 | Prostaglandin derivatives, their preparation and pharmaceutical compositions and intermediates | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1979-01-10 | — | — | EP | claimed |
| US-4306078-A | 16-Substituted prostaglandins | HOFFMANN-LA ROCHE INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4260818-A | ANTISECRETORY, ANTIULCER, HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1981-04-07 | — | — | US | disclosed |
| US-4212993-A | 11-ALKYL-13-SATURATED-15-KETO-16-FLUORO, -ALKYL OR -TRIFLUOROMETHYL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 1980-07-15 | — | — | US | disclosed |
| US-4204074-A | ANTISECRETORY, HYPOTENSIVE, ANTIULCER | HOFFMANN-LA ROCHE INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4163016-A | ANTISECRETORY AGENTS, HYPOTENSIVE AGENTS, ANTIULCER AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1979-07-31 | — | — | US | disclosed |