SCHEMBL11368186

SCHEMBL11368186

Nc1nc(-c2cccnc2)cc2cnccc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.51
PDPK1 O15530 3/20 0.51
KDM4E B2RXH2 8/20 0.49
GAA P10253 5/20 0.49
GLA P06280 4/20 0.49
HSP90AA1 P07900 1/20 0.49
HSP90AB1 P08238 1/20 0.49
PTK2 Q05397 1/20 0.49
ALDH1A1 P00352 6/20 0.48
HPGD P15428 4/20 0.48
TDP1 Q9NUW8 2/20 0.48
MAP4K1 Q92918 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
LMNA P02545 1/20 0.47
HSD17B10 Q99714 2/20 0.46
MEN1 O00255 2/20 0.46
POLB P06746 1/20 0.46
MAPT P10636 1/20 0.46
ALOX15 P16050 1/20 0.46
MAPK1 P28482 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11375277 0.89 KDM4E (0.50) CYP19A1KDM4EGAAGLAALDH1A1
SCHEMBL509836 0.87 CYP11B1 (0.57) CYP19A1PDPK1KDM4EGAAGLA
SCHEMBL11369901 0.87 CYP19A1 (0.51) CYP19A1PDPK1KDM4EGAAGLA
SCHEMBL11374306 0.85 PRKCD (0.56) CYP1A2
SCHEMBL31375795 0.85 PRKCD (0.56) CYP1A2
SCHEMBL11376896 0.82 MAP4K4 (0.49) GLALMNAMAPTCYP2C9CYP2C19
SCHEMBL8218589 0.81 KDM4E (0.49) CYP19A1PDPK1KDM4EGAAGLA
SCHEMBL11366250 0.80 CYP1A2 (0.51) CYP19A1KDM4EALDH1A1SMN1; SMN2LMNA
SCHEMBL11366860 0.79 PRKCD (0.45) KDM4EALDH1A1SMN1; SMN2LMNAHSD17B10
SCHEMBL11369093 0.79 CLK1 (0.45) KDM4ELMNAPOLBADORA2ACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4260759-A CONDENSATION OF NITRILES SCHERING-CORPORATION (US) 1981-04-07 US disclosed
US-4115395-A FUNGICIDES, BACTERICIDES SCHERING CORPORATION (US) 1978-09-19 US disclosed
US-4107166-A ANTIFUNGAL, ANTIBACTERIAL SCHERING CORPORATION (US) 1978-08-15 US disclosed