Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.40 |
| ▸ | CCND3 | P30281 | 2/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCND2 | P30279 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1136839 | 1.00 | ABCB1 (0.43) | ABCB1DYRK2ALKCCND3CDK4 | |
| SCHEMBL1136733 | 0.90 | SRC (0.40) | ALKCDK4CCNA2CDK2CDK9 | |
| SCHEMBL1136737 | 0.90 | SRC (0.40) | ALKCDK4CCNA2CDK2CDK9 | |
| SCHEMBL4790283 | 0.82 | JAK2 (0.35) | ALKJAK2JAK3EGFRHDAC3 | |
| SCHEMBL4790282 | 0.82 | JAK2 (0.35) | ALKJAK2JAK3EGFRHDAC3 | |
| SCHEMBL12864813 | 0.80 | ABCB1 (0.53) | ABCB1ALKCCND3CDK4CCND1 | |
| SCHEMBL1136714 | 0.80 | ABCB1 (0.51) | ABCB1ALKCCND3CDK4CCND1 | |
| SCHEMBL1136716 | 0.80 | ABCB1 (0.51) | ABCB1ALKCCND3CDK4CCND1 | |
| SCHEMBL1136797 | 0.75 | ABCB1 (0.46) | ABCB1ALKCCND3CDK4CCND1 | |
| SCHEMBL1136795 | 0.75 | ABCB1 (0.46) | ABCB1ALKCCND3CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919905-B1 | 3,5-DISUBSTITUTED PYRID-2-ONES USEFUL AS INHIBITORS OF TEC FAMILY OF NON-RECPTOR TYROSINE KINASES | VERTEX PHARMA (US) | 2011-02-23 | — | — | EP | disclosed |
| US-7786120-B2 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-31 | — | — | US | disclosed |
| US-20070185125-A1 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185125-A1 | Pyridones useful as inhibitors of kinases | MAP3K20, MAP3K6, MAP3K5 | ABCB1 1732/4885DYRK2 359/4885ALK 550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.