SCHEMBL11372811

SCHEMBL11372811

O=S(=O)(Cc1ccccc1)Nc1ccc(Nc2ccccc2)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.72
PGR P06401 1/20 0.68
AR P10275 2/20 0.66
HPGD P15428 1/20 0.64
ALOX15 P16050 1/20 0.57
HSD17B10 Q99714 1/20 0.57
MEN1 O00255 1/20 0.57
ALDH1A1 P00352 1/20 0.57
LMNA P02545 1/20 0.57
ADRB2 P07550 1/20 0.57
MAPT P10636 1/20 0.57
HTT P42858 1/20 0.57
HDAC1 Q13547 1/20 0.56
CYP19A1 P11511 1/20 0.54
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
MMP1 P03956 1/20 0.53
MMP2 P08253 1/20 0.53
MMP9 P14780 1/20 0.53
MMP8 P22894 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9479374 1.00 KMT2A (0.72) KMT2APGRARHPGDALOX15
SCHEMBL633995 0.92 KMT2A (0.76) KMT2APGRARHPGDALOX15
SCHEMBL9478969 0.90 KMT2A (0.59) KMT2APGRARHPGDALOX15
SCHEMBL9186300 0.84 KMT2A (0.70) KMT2APGRARHPGDALOX15
SCHEMBL94978 0.84 KMT2A (0.70) KMT2APGRARHPGDALOX15
SCHEMBL6567551 0.84 KMT2A (0.70) KMT2APGRARHPGDALOX15
SCHEMBL4856551 0.84 KMT2A (0.70) KMT2APGRARHPGDALOX15
Hydrochloric Acid SCHEMBL5794620 0.82 KMT2A (0.97) KMT2APGRARHPGDALOX15
SCHEMBL10494714 0.82 KMT2A (0.63) KMT2APGRARHPGDALOX15
SCHEMBL29007532 0.82 IDO1 (0.60) KMT2APGRARHPGDALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4255577-A Process and intermediates for preparing 3-[4-(disubstituted-amino)phenyl] or STERLING DRUG INC. (US) 1981-03-10 US disclosed
US-4200313-A Carbonless duplicating systems STERLING DRUG INC. (US) 1980-04-29 US disclosed
US-4187223-A 3-[4-(Disubstituted-amino)phenyl]-3-(diphenylamino)phthalides STERLING DRUG INC. (US) 1980-02-05 US disclosed