Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 7/20 | 0.57 |
| ▸ | SCN1A | P35498 | 6/20 | 0.57 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.57 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5347764 | 0.87 | SCN5A (0.73) | SCN5ASCN1ASCN9ADRD3CYP3A4 | |
| SCHEMBL5353202 | 0.87 | SCN5A (0.73) | SCN5ASCN1ASCN9ADRD3CYP3A4 | |
| SCHEMBL14429593 | 0.86 | SCN5A (0.59) | SCN5ASCN1ASCN9ADRD3CYP3A4 | |
| SCHEMBL13932644 | 0.86 | SCN5A (0.59) | SCN5ASCN1ASCN9ADRD3CYP3A4 | |
| SCHEMBL11372744 | 0.86 | SCN5A (0.66) | SCN5ASCN1ASCN9ADRD3CYP3A4 | |
| SCHEMBL4340211 | 0.82 | SCN5A (0.55) | SCN5ASCN1ASCN9ADRD3CYP3A4 | |
| SCHEMBL11373680 | 0.82 | SCN5A (0.58) | SCN5ASCN1ASCN9ADRD3CYP3A4 | |
| SCHEMBL11373148 | 0.82 | SCN5A (0.58) | SCN5ASCN1ASCN9ADRD3CYP3A4 | |
| SCHEMBL11470100 | 0.82 | SCN5A (0.52) | SCN5ASCN1ASCN9ADRD3CYP3A4 | |
| SCHEMBL7291659 | 0.81 | CYP2D6 (0.76) | SCN5ADRD3CYP3A4CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4281132-A | HYPOTENSIVE | JOHN WYETH & BROTHER LIMITED (GB) | 1981-07-28 | — | — | US | disclosed |