Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.48 |
| ▸ | PGR | P06401 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11379548 | 1.00 | HIF1A (0.63) | HIF1ALMNANPSR1NR3C1PGR | |
| SCHEMBL11360871 | 0.89 | HIF1A (0.65) | HIF1ALMNANPSR1NR3C1PGR | |
| SCHEMBL10939922 | 0.89 | HIF1A (0.65) | HIF1ALMNANPSR1NR3C1PGR | |
| SCHEMBL10783618 | 0.88 | HIF1A (0.57) | HIF1ALMNANPSR1NR3C1PGR | |
| SCHEMBL11128542 | 0.86 | HIF1A (0.51) | HIF1ALMNANPSR1NR3C1PGR | |
| (6.Alpha.,11.Beta.)-6,9-Difluoro-11,21-Dihydroxy-17-(1-Oxobutoxy)Pregna-1,4-Diene-3,20-Dione SCHEMBL3089453 | 0.86 | HIF1A (0.83) | HIF1ALMNANPSR1NR3C1PGR | |
| (6.Alpha.,11.Beta.)-6,9-Difluoro-11,21-Dihydroxy-17-(1-Oxobutoxy)Pregna-1,4-Diene-3,20-Dione SCHEMBL3089455 | 0.86 | HIF1A (0.83) | HIF1ALMNANPSR1NR3C1PGR | |
| SCHEMBL11370156 | 0.86 | HIF1A (0.69) | HIF1ALMNANPSR1NR3C1PGR | |
| (6.Alpha.,11.Beta.)-6,9-Difluoro-11,21-Dihydroxy-17-(1-Oxobutoxy)Pregna-1,4-Diene-3,20-Dione SCHEMBL3089451 | 0.86 | HIF1A (0.83) | HIF1ALMNANPSR1NR3C1PGR | |
| (6.Alpha.,11.Beta.)-6,9-Difluoro-11,21-Dihydroxy-17-(1-Oxobutoxy)Pregna-1,4-Diene-3,20-Dione SCHEMBL18286134 | 0.86 | HIF1A (0.83) | HIF1ALMNANPSR1NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0029924-A1 | 6-Alpha-fluoro-16-methyl-prednisolone-17,21 diesters and pharmaceutical compositions containing them | STEROSYNT Ltd. (GB) | 1981-06-10 | — | — | EP | disclosed |