Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.50 |
| ▸ | HTR2C | P28335 | 6/20 | 0.50 |
| ▸ | HTR2B | P41595 | 6/20 | 0.50 |
| ▸ | DRD1 | P21728 | 4/20 | 0.40 |
| ▸ | HTR1A | P08908 | 4/20 | 0.40 |
| ▸ | DRD4 | P21917 | 4/20 | 0.40 |
| ▸ | DRD3 | P35462 | 4/20 | 0.40 |
| ▸ | HTR1D | P28221 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11387254 | 0.85 | HTR2A (0.50) | HTR2AHTR2CHTR2BDRD1HTR1A | |
| SCHEMBL11377237 | 0.80 | HTR2A (0.57) | HTR2AHTR2CHTR2BDRD1HTR1A | |
| SCHEMBL11392239 | 0.80 | HTR2A (0.48) | HTR2AHTR2CHTR2BHTR1ADRD4 | |
| SCHEMBL11381341 | 0.76 | HTR2A (0.47) | HTR2AHTR2CHTR2BDRD1HTR1A | |
| SCHEMBL11390390 | 0.75 | HTR2C (0.65) | HTR2AHTR2CHTR2B | |
| SCHEMBL11385117 | 0.73 | HTR2A (0.51) | HTR2AHTR2CHTR2BHTR1ADRD4 | |
| SCHEMBL11386254 | 0.72 | CYP3A4 (0.44) | HTR2AHTR2CHTR2BDRD1HTR1A | |
| SCHEMBL11390523 | 0.69 | DRD1 (0.52) | HTR2ADRD1DRD4DRD3DRD2 | |
| SCHEMBL11302850 | 0.69 | HTR2A (0.53) | HTR2AHTR2CHTR2BDRD1HTR1A | |
| SCHEMBL24711417 | 0.68 | KDM4E (0.42) | KDM4EALDH1A1ANPEPDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4273773-A | IN COMBINATION WITH A DIURETIC | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-06-16 | — | — | US | disclosed |