⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propyne SCHEMBL250724 | 0.93 | GRM5 (0.48) | — | |
| SCHEMBL13907283 | 0.82 | GRM5 (0.70) | — | |
| SCHEMBL5742874 | 0.78 | GRM5 (0.38) | — | |
| SCHEMBL12295340 | 0.76 | GRM5 (0.37) | — | |
| SCHEMBL13907290 | 0.74 | GRM5 (0.77) | — | |
| SCHEMBL15957833 | 0.74 | GRM5 (0.40) | — | |
| SCHEMBL2160719 | 0.74 | GRM5 (0.50) | — | |
| SCHEMBL13499904 | 0.74 | HSP90AA1 (0.38) | — | |
| SCHEMBL20409161 | 0.72 | — | — | |
| SCHEMBL16077763 | 0.72 | GRM5 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2329 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11466273-B2 | Monocarboxylate transporter 4 (MCT4) antisense oligonucleotide (ASO) inhibitors for use as therapeutics in the treatment of cancer | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2022-10-11 | — | — | US | claimed |
| US-20210395733-A1 | Monocarboxylate Transporter 4 (MCT4) Antisense Oligonucleotide (ASO) Inhibitors For Use As Therapeutics In The Treatment Of Cancer | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2021-12-23 | — | — | US | claimed |
| EP-3194597-B1 | ALLELE-SPECIFIC THERAPY FOR HUNTINGTON DISEASE HAPLOTYPES | UNIV BRITISH COLUMBIA (CA) | 2021-06-30 | — | — | EP | claimed |
| EP-3384028-B1 | MONOCARBOXYLATE TRANSPORTER 4 (MCT4) ANTISENSE OLIGONUCLEOTIDE (ASO) INHIBITORS FOR USE AS THERAPEUTICS IN THE TREATMENT OF CANCER | UNIV BRITISH COLUMBIA (CA) | 2021-06-30 | — | — | EP | claimed |
| EP-3778618-A1 | SELECTIVE ANTISENSE COMPOUNDS AND USES THEREOF | Ionis Pharmaceuticals, Inc. (US) | 2021-02-17 | — | — | EP | claimed |
| US-10889814-B2 | Monocarboxylate transporter 4 (MCT4) antisense oligonucleotide (ASO) inhibitors for use as therapeutics in the treatment of cancer | THE UNIVERSITY OF BRITISH COLUMBIA | 2021-01-12 | — | — | US | claimed |
| EP-2951304-B1 | SELECTIVE ANTISENSE COMPOUNDS AND USES THEREOF | IONIS PHARMACEUTICALS INC (US) | 2020-07-08 | — | — | EP | claimed |
| EP-3205725-B1 | SELECTIVE ANTISENSE COMPOUNDS AND USES THEREOF | IONIS PHARMACEUTICALS INC (US) | 2019-03-27 | — | — | EP | claimed |
| US-20190010492-A1 | MONOCARBOXYLATE TRANSPORTER 4 (MCT4) ANTISENSE OLIGONUCLEOTIDE (ASO) INHIBITORS FOR USE AS THERAPEUTICS IN THE TREATMENT OF CANCER | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2019-01-10 | — | — | US | claimed |
| EP-3384028-A1 | MONOCARBOXYLATE TRANSPORTER 4 (MCT4) ANTISENSE OLIGONUCLEOTIDE (ASO) INHIBITORS FOR USE AS THERAPEUTICS IN THE TREATMENT OF CANCER | The University Of British Columbia (CA) | 2018-10-10 | — | — | EP | claimed |
| US-20020182597-A1 | ADDRESSABLE PROTEIN ARRAYS | ADNEXUS THERAPEUTICS, INC. | 2002-12-05 | — | — | US | claimed |
| EP-1251183-A2 | Improved helper probes for detection of a target sequence by a capture oligonucleotide | Exiqon A/S (DK) | 2002-10-23 | — | — | EP | claimed |
| EP-1247815-A2 | Modified oligonucleotides and uses thereof | Exiqon A/S (DK) | 2002-10-09 | — | — | EP | claimed |
| WO-2002068691-A1 | METHODS FOR IDENTIFYING LIGAND BINDING SITES IN A BIOMOLECULE | ISIS PHARMACEUTICALS, INC. (US) | 2002-09-06 | — | — | WO | claimed |
| JP-2002510505-A | — | — | 2002-04-09 | — | — | JP | claimed |
| EP-1068356-A4 | ADDRESSABLE PROTEIN ARRAYS | PHYLOS INC (US) | 2001-09-05 | — | — | EP | claimed |
| EP-1068356-A1 | ADDRESSABLE PROTEIN ARRAYS | Compound Therapeutics, Inc. (US) | 2001-01-17 | — | — | EP | claimed |
| WO-1999051773-A9 | ADDRESSABLE PROTEIN ARRAYS | PHYLOS INC (US) | 2000-02-03 | — | — | WO | claimed |
| WO-1999051773-A1 | ADDRESSABLE PROTEIN ARRAYS | PHYLOS, INC. (US) | 1999-10-14 | — | — | WO | claimed |
| US-5446137-A | Substituent selected from linking group containing modifiers such as biotin, reactive groups, nucleic acids, catalysts, DNA intercalators, minor groove binders, clevage agents, and detectable labels | SYNTEX (U.S.A.) INC. (US) | 1995-08-29 | — | — | US | claimed |