Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 0.80 |
| ▸ | HRH2 | P25021 | 2/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.80 |
| ▸ | GLA | P06280 | 1/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.80 |
| ▸ | TSHR | P16473 | 1/20 | 0.80 |
| ▸ | ATP4A | P20648 | 1/20 | 0.80 |
| ▸ | APEX1 | P27695 | 1/20 | 0.80 |
| ▸ | PDE4A | P27815 | 1/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.80 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.80 |
| ▸ | ATP4B | P51164 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.80 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.80 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10852820 | 0.96 | SLC47A1 (0.74) | SLC47A1HRH2SMN1; SMN2MEN1SLC22A2 | |
| Hydrochloric Acid SCHEMBL11381235 | 0.92 | SLC47A1 (0.73) | SLC47A1HRH2SMN1; SMN2MEN1SLC22A2 | |
| SCHEMBL11163179 | 0.91 | SLC47A1 (0.67) | SLC47A1HRH2SMN1; SMN2MEN1SLC22A2 | |
| Cimetidine SCHEMBL534523 | 0.89 | CYP3A4 (1.00) | SLC47A1HRH2SMN1; SMN2MEN1SLC22A2 | |
| Cimetidine SCHEMBL3735476 | 0.89 | CYP3A4 (1.00) | SLC47A1HRH2SMN1; SMN2MEN1SLC22A2 | |
| Cimetidine SCHEMBL226031 | 0.89 | CYP3A4 (1.00) | SLC47A1HRH2SMN1; SMN2MEN1SLC22A2 | |
| SCHEMBL14175415 | 0.89 | HRH2 (0.79) | SLC47A1HRH2SMN1; SMN2MEN1SLC22A2 | |
| Cimetidine SCHEMBL1736444 | 0.88 | CYP3A4 (0.98) | SLC47A1HRH2SMN1; SMN2MEN1SLC22A2 | |
| Cimetidine SCHEMBL22127097 | 0.88 | CYP3A4 (0.98) | SLC47A1HRH2SMN1; SMN2MEN1SLC22A2 | |
| Cimetidine SCHEMBL1736443 | 0.88 | CYP3A4 (0.98) | SLC47A1HRH2SMN1; SMN2MEN1SLC22A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4107319-A | GUANIDINES, BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-15 | — | — | US | claimed |
| US-4282234-A | HISTAMINE BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-08-04 | — | — | US | disclosed |
| US-4282234-A | HISTAMINE BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-08-04 | — | — | US | disclosed |
| US-4191769-A | HISTAMINE ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-03-04 | — | — | US | disclosed |
| US-4191769-A | HISTAMINE ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-03-04 | — | — | US | disclosed |
| US-4170652-A | USED TO BLOCK HISTAMINE H2 RECEPTORS ANTISECRETORY, ANTIINFLAMMATORY | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-10-09 | — | — | US | disclosed |
| US-4170652-A | USED TO BLOCK HISTAMINE H2 RECEPTORS ANTISECRETORY, ANTIINFLAMMATORY | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-10-09 | — | — | US | disclosed |
| US-4118496-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-10-03 | — | — | US | disclosed |
| US-4118496-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-10-03 | — | — | US | disclosed |
| US-4109003-A | N-(IMIDAZOLYL-METHYLTHIO-ALKYL) DERIVATIVES OF S-ALKYL ISOTHIOUREAS; ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-22 | — | — | US | disclosed |
| US-4109003-A | N-(IMIDAZOLYL-METHYLTHIO-ALKYL) DERIVATIVES OF S-ALKYL ISOTHIOUREAS; ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-22 | — | — | US | disclosed |
| US-4107319-A | GUANIDINES, BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-15 | — | — | US | disclosed |
| US-4107319-A | GUANIDINES, BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-15 | — | — | US | disclosed |
| US-4036971-A | HISTAMINE H(2) ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-07-19 | — | — | US | disclosed |