Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.50 |
| ▸ | CCR5 | P51681 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2855618 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9ACYP2C19FKBP1A | |
| SCHEMBL5493772 | 0.84 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9ACYP2C19FKBP1A | |
| SCHEMBL5866430 | 0.83 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9ACYP2C19FKBP1A | |
| SCHEMBL2862814 | 0.82 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9ACYP2C19FKBP1A | |
| SCHEMBL2861159 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9ACYP2C19FKBP1A | |
| SCHEMBL5866405 | 0.81 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9ACYP2C19FKBP1A | |
| SCHEMBL2859914 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ACYP2C19FKBP1A | |
| SCHEMBL2860475 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9ACYP2C19FKBP1A | |
| SCHEMBL3534026 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9ACYP2C19FKBP1A | |
| SCHEMBL11386910 | 0.78 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9ACYP2C19FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4264599-A | HYPOTENSIVE AGENTS, ADRENERGIC BLOCKING AGENTS | CIBA-GEIGY CORPORATION (US) | 1981-04-28 | — | — | US | disclosed |
| EP-0000485-A1 | Piperidino-propanols, their preparation and pharmaceutical compounds containing them | CIBA-GEIGY AG (CH) | 1979-02-07 | — | — | EP | disclosed |