Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ABCC9 | O60706 | 4/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.43 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11399162 | 1.00 | KDM4E (0.50) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL11399157 | 1.00 | KDM4E (0.50) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL11395222 | 0.99 | KDM4E (0.48) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL11395217 | 0.99 | KDM4E (0.48) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL11395215 | 0.99 | KDM4E (0.48) | KDM4EALDH1A1MAPTGAAHPGD | |
| Methane SCHEMBL11394028 | 0.98 | KDM4E (0.47) | KDM4EALDH1A1MAPTGAAHPGD | |
| Methane SCHEMBL11394031 | 0.98 | KDM4E (0.47) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL11390779 | 0.87 | KDM4E (0.53) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL11390784 | 0.87 | KDM4E (0.53) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL11390777 | 0.87 | KDM4E (0.53) | KDM4EALDH1A1MAPTGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4251537-A | Hypotensive 3,4-dihydro-2,2-dimethyl-4-amino-2H-benzo[b]pyran-3-ols | BEECHAM GROUP LIMITED (GB) | 1981-02-17 | — | — | US | claimed |
| US-4251537-A | Hypotensive 3,4-dihydro-2,2-dimethyl-4-amino-2H-benzo[b]pyran-3-ols | BEECHAM GROUP LIMITED (GB) | 1981-02-17 | — | — | US | disclosed |