Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1140187 | 0.89 | MAPK14 (0.60) | MAPK14 | |
| SCHEMBL1140284 | 0.83 | MAPK14 (0.70) | MAPK14 | |
| SCHEMBL1140594 | 0.82 | MAPK14 (0.69) | MAPK14 | |
| SCHEMBL1140517 | 0.82 | MAPK14 (0.62) | MAPK14 | |
| SCHEMBL1140155 | 0.80 | MAPK14 (0.62) | MAPK14 | |
| SCHEMBL1140549 | 0.80 | MAPK14 (0.69) | MAPK14 | |
| SCHEMBL3144145 | 0.80 | MAPK14 (0.53) | MAPK14HPGDHTTNPSR1RPS6KA5 | |
| SCHEMBL3145748 | 0.79 | MAPK14 (0.48) | MAPK14HPGDHTTNPSR1RPS6KA5 | |
| SCHEMBL4889085 | 0.79 | MAPK14 (0.51) | MAPK14NPSR1 | |
| SCHEMBL1140248 | 0.78 | MAPK14 (0.64) | MAPK14MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682520-B1 | AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2011-02-23 | — | — | EP | claimed |
| EP-1682520-A1 | AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005042502-A1 | AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-05-12 | — | — | WO | disclosed |