Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29395562 | 0.85 | PDE4A (0.60) | GAACA12CA1CA2CA9 | |
| SCHEMBL11397866 | 0.84 | MAPT (0.49) | GAACA12CA1CA2CA9 | |
| SCHEMBL23534153 | 0.81 | GAA (0.54) | GAACA12CA1CA2CA9 | |
| SCHEMBL29394932 | 0.77 | CA12 (0.68) | GAACA12CA1CA2CA9 | |
| SCHEMBL11398931 | 0.77 | CD274 (0.59) | GAACA12CA1CA2CA9 | |
| SCHEMBL11399660 | 0.74 | PDE4B (0.55) | GAAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6014889 | 0.73 | CA12 (0.71) | GAACA12CA1CA2CA9 | |
| SCHEMBL29394845 | 0.73 | PDE4A (0.56) | GAACA12CA1CA2CA9 | |
| SCHEMBL21144550 | 0.72 | PDE4B (0.52) | GAAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11732162 | 0.72 | MEN1 (0.61) | GAACA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4289774-A | Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a process for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-09-15 | — | — | US | disclosed |
| EP-0010156-A1 | 6-Arylpyridazine-3-ones, pharmaceutical compositions containing them and process for their preparation | MERCK PATENT GmbH (DE) | 1980-04-30 | — | — | EP | disclosed |