Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HBB | P68871 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11407408 | 1.00 | MEN1 (0.50) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL6804513 | 0.91 | — | — | |
| Bicarbonate SCHEMBL9524362 | 0.91 | — | — | |
| Bicarbonate SCHEMBL28311889 | 0.91 | — | — | |
| Bicarbonate SCHEMBL9614727 | 0.91 | — | — | |
| Bicarbonate SCHEMBL11287089 | 0.91 | MEN1 (0.50) | MEN1KMT2ACA5ACA5BCA1 | |
| Hydrogen Peroxide SCHEMBL3880127 | 0.91 | — | — | |
| Hydrogen Peroxide SCHEMBL3880134 | 0.91 | MEN1 (0.60) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL20740773 | 0.87 | MEN1 (0.46) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL11752204 | 0.87 | MEN1 (0.46) | MEN1KMT2ACA5ACA5BCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031697-A2 | Improved process for coking petroleum residua and production of methane therefrom | THE STANDARD OIL COMPANY (US) | 1981-07-08 | — | — | EP | disclosed |