Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11508 | 0.90 | BACE1 (0.73) | BACE1CTSD | |
| SCHEMBL14321494 | 0.86 | BACE1 (0.82) | BACE1 | |
| SCHEMBL11458 | 0.84 | BACE1 (0.65) | BACE1CTSD | |
| SCHEMBL14321154 | 0.84 | BACE1 (0.65) | BACE1CTSD | |
| SCHEMBL11539 | 0.84 | BACE1 (0.65) | BACE1CTSD | |
| SCHEMBL17620362 | 0.81 | BACE1 (0.91) | BACE1CTSD | |
| SCHEMBL11963 | 0.78 | BACE1 (0.70) | BACE1CTSD | |
| SCHEMBL11906 | 0.76 | BACE1 (0.73) | BACE1CTSD | |
| SCHEMBL11772 | 0.76 | BACE1 (0.52) | BACE1CTSD | |
| SCHEMBL11771 | 0.76 | BACE1 (0.52) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504315-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2012-10-03 | — | — | EP | claimed |
| WO-2011063233-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | claimed |
| EP-2504315-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011063233-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |