Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.69 |
| ▸ | ACE | P12821 | 10/20 | 0.60 |
| ▸ | MME | P08473 | 7/20 | 0.60 |
| ▸ | CPA1 | P15085 | 2/20 | 0.60 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.60 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11414971 | 0.91 | NAALAD2 (0.57) | NAALAD2ACEMMECPA1ACE2 | |
| SCHEMBL11411467 | 0.88 | MME (0.56) | NAALAD2ACEMMECPA1ACE2 | |
| SCHEMBL11422246 | 0.86 | ACE (0.62) | NAALAD2ACEMMECPA1ACE2 | |
| SCHEMBL31610861 | 0.85 | NAALAD2 (0.67) | NAALAD2ACEMMECPA1ACE2 | |
| SCHEMBL11570507 | 0.84 | NAALAD2 (0.66) | NAALAD2ACEMMECPA1ACE2 | |
| SCHEMBL159463 | 0.84 | NAALAD2 (0.69) | NAALAD2ACEMMECPA1ACE2 | |
| SCHEMBL27412431 | 0.84 | NAALAD2 (0.69) | NAALAD2ACEMMECPA1ACE2 | |
| SCHEMBL159464 | 0.84 | NAALAD2 (0.69) | NAALAD2ACEMMECPA1ACE2 | |
| SCHEMBL31615028 | 0.84 | NAALAD2 (0.65) | NAALAD2ACEMMECPA1ACE2 | |
| SCHEMBL6163836 | 0.83 | MME (0.70) | ACEMMECPA1ACE2FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4228184-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1980-10-14 | — | — | US | disclosed |
| US-4207336-A | AGIOTENSIN RELATED HYPERTENSION | E. R. SQUIBB & SONS, INC. (US) | 1980-06-10 | — | — | US | disclosed |
| US-4207342-A | Relieving hypertension with carboxyalkylacylamino acids | E. R. SQUIBB & SONS, INC. (US) | 1980-06-10 | — | — | US | disclosed |
| US-4207337-A | ESPECIALLY ANGIOTENSIN RELATED HYPERTENSION | E. R. SQUIBB & SONS, INC. (US) | 1980-06-10 | — | — | US | disclosed |
| US-4206232-A | Relieving hypertension with carboxyalkylacylamino acids | E. R. SQUIBB & SONS, INC. (US) | 1980-06-03 | — | — | US | disclosed |
| US-4200649-A | Relieving hypertension with carboxyalkylacylamino acids | E. R. SQUIBB & SONS, INC. (US) | 1980-04-29 | — | — | US | disclosed |
| US-4192882-A | SUBSTITUTED INDOLES FOR RELIEVING ANGIOTENSIN RELATED HYPERTENSION | E. R. SQUIBB & SONS, INC. (US) | 1980-03-11 | — | — | US | disclosed |
| US-4192881-A | RELIEVING ANGIOTENSIN RELATED HYPERTENSION | E. R. SQUIBB & SONS, INC. (US) | 1980-03-11 | — | — | US | disclosed |
| US-4153725-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-05-08 | — | — | US | disclosed |
| US-4146641-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-03-27 | — | — | US | disclosed |
| US-4146639-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-03-27 | — | — | US | disclosed |
| US-4105789-A | Carboxyalkylacylamino acids | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |