Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 4/20 | 0.58 |
| ▸ | CA1 | P00915 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11423398 | 1.00 | DHODH (0.64) | DHODHCA2CA1KMT2AKDM4E | |
| SCHEMBL17973873 | 0.82 | KDM4E (0.55) | DHODHCA2CA1KMT2AKDM4E | |
| SCHEMBL28599218 | 0.82 | KDM4E (0.55) | DHODHCA2CA1KMT2AKDM4E | |
| SCHEMBL11437008 | 0.81 | DHODH (0.64) | DHODHCA2CA1KMT2AKDM4E | |
| SCHEMBL11437006 | 0.81 | DHODH (0.64) | DHODHCA2CA1KMT2AKDM4E | |
| SCHEMBL11409847 | 0.81 | DHODH (0.64) | DHODHCA2CA1KMT2AKDM4E | |
| SCHEMBL11422552 | 0.75 | DHODH (0.61) | DHODHCA2CA1KMT2AKDM4E | |
| SCHEMBL11438306 | 0.75 | DHODH (0.61) | DHODHCA2CA1KMT2AKDM4E | |
| SCHEMBL11438310 | 0.75 | DHODH (0.61) | DHODHCA2CA1KMT2AKDM4E | |
| SCHEMBL11422550 | 0.75 | DHODH (0.61) | DHODHCA2CA1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4200648-A | INFLAMMATION BY ADMINISTERING A BENZYLIDENEANILINE DERIVATIVE | WILLIAM H. RORER, INC. (US) | 1980-04-29 | — | — | US | disclosed |
| US-4198349-A | ANTIINFLAMMATORY, TOPICAL | WILLIAM H. RORER, INC. (US) | 1980-04-15 | — | — | US | disclosed |