SCHEMBL11425499

SCHEMBL11425499

CN1CCc2c(n(C)c3cc(-n4ccc(-c5ccc(C=O)cc5F)cc4=O)ccc23)C1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 20/20 0.66
CYP3A4 P08684 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3475491 0.86 MCHR1 (0.66) MCHR1CYP3A4
SCHEMBL15889612 0.85 MCHR1 (0.65) MCHR1CYP3A4
Hydrochloric Acid SCHEMBL3477120 0.85 MCHR1 (0.65) MCHR1CYP3A4
SCHEMBL18870420 0.85 MCHR1 (0.64) MCHR1CYP3A4
Hydrochloric Acid SCHEMBL3476633 0.83 MCHR1 (0.62) MCHR1CYP3A4
SCHEMBL19147948 0.82 MCHR1 (0.80) MCHR1CYP3A4
SCHEMBL11423814 0.80 MCHR1 (0.71) MCHR1CYP3A4
SCHEMBL11424218 0.80 MCHR1 (1.00) MCHR1CYP3A4
Hydrochloric Acid SCHEMBL3475374 0.79 MCHR1 (0.70) MCHR1CYP3A4
Hydrochloric Acid SCHEMBL3477092 0.79 MCHR1 (0.98) MCHR1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2476680-A1 (1-Azinone)-Substituted Pyridoindoles Albany Molecular Research, Inc. (US) 2012-07-18 EP disclosed
WO-2009089482-A1 (1-AZINONE) -SUBSTITUTED PYRIDOINDOLES AS MCH ANTAGONISTS ALBANY MOLECULAR RESEARCH, INC. (US) 2009-07-16 WO disclosed