Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
| ▸ | MIF | P14174 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11434009 | 0.85 | TDP1 (0.36) | POLBL3MBTL1TDP1ALDH1A1KMT2A | |
| SCHEMBL11495137 | 0.82 | MIF (0.35) | L3MBTL1TDP1ALDH1A1KMT2AMIF | |
| SCHEMBL11425166 | 0.82 | MIF (0.35) | L3MBTL1TDP1ALDH1A1KMT2AMIF | |
| SCHEMBL11433432 | 0.80 | MIF (0.37) | ALDH1A1EPHX2MIF | |
| SCHEMBL31645448 | 0.79 | BRD4 (0.49) | BRD4POLBL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL337398 | 0.79 | BRD4 (0.49) | BRD4POLBL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL30045918 | 0.79 | BRD4 (0.49) | BRD4POLBL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL10413120 | 0.74 | BRD4 (0.47) | BRD4POLBL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL868953 | 0.73 | BRD4 (0.47) | BRD4POLBL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL3631878 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4222944-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-09-16 | — | — | US | disclosed |
| US-4192809-A | USED A ANTIINFLAMMATORY, ANALGESIC, AND ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-03-11 | — | — | US | disclosed |
| US-4097497-A | ANTIINFLAMMATORY, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1978-06-27 | — | — | US | disclosed |
| US-4022805-A | ANTIINFLAMMATORY, ANALGESIC, ANTIRHEUMATIC | HOFFMANN-LA ROCHE INC. (US) | 1977-05-10 | — | — | US | disclosed |