Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.49 |
| ▸ | MTOR | P42345 | 6/20 | 0.49 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL115191 | 0.91 | PIK3CA (0.56) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL115088 | 0.90 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL115718 | 0.87 | PIK3CA (0.45) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL114526 | 0.87 | PIK3CA (0.54) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL116075 | 0.85 | PIK3CA (0.51) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL116537 | 0.84 | FLT3 (0.49) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL116174 | 0.84 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL113367 | 0.84 | PIK3CA (0.44) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL164330 | 0.83 | FLT3 (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL116967 | 0.83 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |