⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1145753 | 0.97 | — | — | |
| SCHEMBL1145616 | 0.97 | EPHX1 (0.36) | — | |
| SCHEMBL1145459 | 0.97 | EPHX1 (0.36) | — | |
| SCHEMBL1145163 | 0.94 | — | — | |
| SCHEMBL8976389 | 0.73 | EPHX1 (0.35) | — | |
| Ammonia Solution, Strong SCHEMBL28811026 | 0.71 | EPHX1 (0.34) | — | |
| SCHEMBL7440315 | 0.71 | EPHX1 (0.39) | — | |
| SCHEMBL3051329 | 0.71 | — | — | |
| SCHEMBL8023973 | 0.71 | — | — | |
| SCHEMBL1145794 | 0.69 | CYP1A2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888374-B2 | Inhibitors of c-jun N-terminal kinases | ABBOTT LABORATORIES (US) | 2011-02-15 | — | — | US | disclosed |
| WO-2006083673-A2 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF C-JUN N-TERMINAL KINASES | ABBOTT LABORATORIES (US) | 2006-08-10 | — | — | WO | disclosed |
| US-20060173050-A1 | Inhibitors of c-Jun N-terminal kinases | ABBVIE INC. | 2006-08-03 | — | — | US | disclosed |
| US-20050171132-A1 | Diaminopyrimidine derivatives as selective growth hormone secrectgogue receptor (GHS-R) antagonists | XIN ZHILI (US) | 2005-08-04 | — | — | US | disclosed |
| US-20050171131-A1 | Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists | KOSOGOF CHRISTI (US) | 2005-08-04 | — | — | US | disclosed |
| WO-2005030734-A1 | DIAMINOPYRIMIDINE DERIVATIVES AS SELECTIVE GROWTH HORMONE SECRECTGOGUE RECEPTOR (GHS-R) ANTAGONISTS | ABBOTT LABORATORIES (US) | 2005-04-07 | — | — | WO | disclosed |
| US-20050070712-A1 | Pyrimidine derivatives as ghrelin receptor modulators | ABBOTT LABORATORIES | 2005-03-31 | — | — | US | disclosed |
| US-5569665-A | Peptidyl derivatives and their use as metalloproteinases inhibitors | CELLTECH LIMITED (GB) | 1996-10-29 | — | — | US | disclosed |
| US-5530128-A | ENZYME INHIBITOR AS ANTITUMOR AGENT | CELLTECH THERAPEUTICS LIMITED (GB) | 1996-06-25 | — | — | US | disclosed |
| EP-0489577-B1 | Peptidyl derivatives | CELLTECH LTD (GB) | 1995-03-22 | — | — | EP | disclosed |
| EP-0605681-A1 | SULPHAMIDE DERIVATIVES AS METALLOPROTEINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1994-07-13 | — | — | EP | disclosed |
| EP-0605682-A1 | PEPTIDYL DERIVATIVES AND THEIR USE AS METALLOPROTEINASES INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1994-07-13 | — | — | EP | disclosed |
| US-5300501-A | Metalloproteinase inhibitors | CELLTECH LIMITED (GB) | 1994-04-05 | — | — | US | disclosed |
| WO-1993024475-A1 | SULPHAMIDE DERIVATIVES AS METALLOPROTEINASE INHIBITORS | CELLTECH LIMITED (GB) | 1993-12-09 | — | — | WO | disclosed |
| WO-1993024449-A1 | PEPTIDYL DERIVATIVES AND THEIR USE AS METALLOPROTEINASES INHIBITORS | CELLTECH LIMITED (GB) | 1993-12-09 | — | — | WO | disclosed |
| WO-1992009565-A1 | PEPTIDYL DERIVATIVES | CELLTECH LIMITED (GB) | 1992-06-11 | — | — | WO | disclosed |
| EP-0489577-A1 | Peptidyl derivatives | CELLTECH LIMITED (GB) | 1992-06-10 | — | — | EP | disclosed |