Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 6/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11446101 | 0.84 | MAPT (0.39) | MAPTKDM4EALDH1A1GAABRD4 | |
| SCHEMBL11445269 | 0.82 | PTPN1 (0.39) | MAPTKDM4EALDH1A1PTPN1HTR2C | |
| SCHEMBL11453539 | 0.75 | HSD17B3 (0.37) | MAPTGSK3BL3MBTL1ALOX15 | |
| Hydrochloric Acid SCHEMBL11446361 | 0.74 | HSD17B3 (0.36) | MAPTGSK3BL3MBTL1ALOX15 | |
| SCHEMBL10620834 | 0.71 | GSK3B (0.42) | MAPTALDH1A1GAAGSK3BTSHR | |
| SCHEMBL10542749 | 0.68 | GAA (0.32) | MAPTKDM4EALDH1A1GAATSHR | |
| SCHEMBL11446349 | 0.68 | MEN1 (0.41) | MAPTKDM4EALDH1A1GAABRD4 | |
| SCHEMBL10475097 | 0.66 | HTR2A (0.40) | HTR2CMAPK1 | |
| SCHEMBL10542971 | 0.66 | MAPT (0.44) | MAPTKDM4EALDH1A1HTR2CTSHR | |
| SCHEMBL10621317 | 0.66 | GSK3B (0.44) | MAPTGSK3BTSHRALOX15BRCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4186199-A | Indolo-,1,2-dihydroindolo-, and 1,2,6,7-tetrahydroindolo [1,7-ab][1,5] benzodiazepines | AMERICAN HOECHST CORPORATION (US) | 1980-01-29 | — | — | US | claimed |
| US-4186199-A | Indolo-,1,2-dihydroindolo-, and 1,2,6,7-tetrahydroindolo [1,7-ab][1,5] benzodiazepines | AMERICAN HOECHST CORPORATION (US) | 1980-01-29 | — | — | US | disclosed |