Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | HPGD | P15428 | 4/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.62 |
| ▸ | APEX1 | P27695 | 4/20 | 0.62 |
| ▸ | RECQL | P46063 | 4/20 | 0.62 |
| ▸ | BLM | P54132 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.62 |
| ▸ | FYN | P06241 | 2/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11447283 | 1.00 | KDM4E (0.62) | KDM4EMAPTHSD17B10TDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11447351 | 0.99 | KDM4E (0.61) | KDM4EMAPTHSD17B10TDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11447349 | 0.99 | KDM4E (0.61) | KDM4EMAPTHSD17B10TDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11447186 | 0.97 | KDM4E (0.59) | KDM4EMAPTHSD17B10TDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11447187 | 0.97 | KDM4E (0.59) | KDM4EMAPTHSD17B10TDP1ALDH1A1 | |
| Methyldopate SCHEMBL11430187 | 0.86 | HSD17B10 (0.66) | KDM4EMAPTHSD17B10TDP1ALDH1A1 | |
| Methyldopate SCHEMBL297359 | 0.86 | HSD17B10 (0.66) | KDM4EMAPTHSD17B10TDP1ALDH1A1 | |
| Methyldopate SCHEMBL29587132 | 0.86 | HSD17B10 (0.66) | KDM4EMAPTHSD17B10TDP1ALDH1A1 | |
| SCHEMBL24761068 | 0.84 | KDM4E (0.64) | KDM4EMAPTHSD17B10TDP1ALDH1A1 | |
| Methyldopate SCHEMBL41131 | 0.84 | KDM4E (0.64) | KDM4EMAPTHSD17B10TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4198413-A | HYPOTENSIVE AGENTS | MERCK & CO., INC. (US) | 1980-04-15 | — | — | US | disclosed |
| US-4143146-A | HYPOTENSIVE AGENTS | MERCK & CO., INC. (US) | 1979-03-06 | — | — | US | disclosed |
| US-4058530-A | PHENYLALANINE, ANTIHYPERTENSIVE | MERCK & CO., INC. (US) | 1977-11-15 | — | — | US | disclosed |
| US-4051169-A | HYPOTENSIVE AGENTS | MERCK & CO., INC. (US) | 1977-09-27 | — | — | US | disclosed |
| US-4038411-A | ANTIHYPERTENSIVE AMINO ACID ESTERS | MERCK & CO., INC. (US) | 1977-07-26 | — | — | US | disclosed |
| US-3983138-A | HYPOTENSIVES | MERCK & CO., INC. (US) | 1976-09-28 | — | — | US | disclosed |